The world's first animal welfare charity, it has branches covering the length and breadth of the country, including here in Sheffield, supported by a dedicated band of fundraisers.
Here, we take a look in our archive at some pictures from the past.
1. Geese rescue
RSPCA officers rescue geese in Endcliffe Park in December 1964 Photo: Sheffield Newspapers
2. Puppy love
Helen Goodwin right, and Leanne Booth left with abandoned puppies at the RSPCA, Spring Street, Sheffield in January 2001 Photo: Stuart Hastings (Staff)
3. Raising funds
An RSPCA fundraiser, in Spring Street, Sheffield - July 2003 Photo: Andrew Partridge
4. Abandoned puppies
Howard Parker, kennels manager, and kennel girl Lynne Jackson pictured with abandoned puppies at Sheffield RSPCA on December 23 1985 Photo: Nancy Fielder