The company is opening a restaurant at 3 The Moor next to H&M.
Hoardings have gone up around the premises. The company’s website confirms that it is opening ’very soon’.
It will have competition from Nando’s, Fat Hippo, El Paso, Dough & Co, Subway and Poundbakery.
It already has outlets at Meadowhall and Valley Centertainment in Attercliffe.
A large Sports Direct is set to open in the former TJ Hughes department store near Cumberland Street in July, with a St Luke’s charity shop opposite.
Founded in Arlington, Virginia, by the Murrell family, Five Guys employs 5,000 people, has 1,674 stores and had sales of $1.7bn last year.