Glenn Loovens has ‘less than a 50-50 chance’ of being fit to face Brighton on Saturday after suffering an ankle injury.
The Owls skipper was due to make his return to the side after serving a two match ban for picking up ten yellow cards this season.
But his place is in major doubt after rolling his ankle in training earlier this week.
Head coach Stuart Gray – who will this afternoon meet with the club’s new owners – said: “Glenn’s picked up an injury in training.
“He is touch and go for Saturday. He’s had to have a scan on his ankle.
“At the moment, he’s got a boot on and he can’t put any weight on his right ankle.
“It was a clash in his ankle where he rolled his ankle.
“The most important thing is when he comes back he stays back but we have missed him and Semi. That’s the spine of the team.”
Gray was more positive about Jose Semedo’s prospects of being fit for the weekend.
The midfielder missed Tuesday’s defeat at Ipswich due to a toe infection which flared up after playing the second half of last weekend’s clash with Cardiff.
Semedo sat out training at Middlewood Road today but Gray insists he has a chance to be ready for the weekend.
He said: “He has not trained today. He’s still getting the swollen down. We will review it tomorrow.
“He might have a fitness test tomorrow or Saturday. He’s going in the right direction.
“We didn’t want him to train today just in case it flared up.
“I’m sure he’s very confident he will be okay for Saturday.”