Carlos Carvalhal says Gary Hooper looks set for a spell on the sidelines after picking up an injury in last week's draw with Fulham.
Sheffield Wednesday head coach Carvalhal will be forced into a reshuffle up front for the trip to Wolves on Saturday, though Daniel Pudil could return to the line-up at left back after missing last week's match at Craven Cottage.
Adam Reach deputised for Pudil but his talents are much more suited to be playing further up the pitch.
Hooper's absence is a blow for the Owls as his performances have been impressive in the past few games, but Carvalhal said it is now an opportunity for another forward to stake their claim for a place, with Lucas Joao now ready for a recall.
"Gary Hooper will be out for some time with his injury," said Carvalhal in his weekly press briefing. "He played very well last week (at Fulham), he is doing well and finding goals but this is the life, he is not available to play, we have more players to play in attack. We like to have all the players and Gary is an important player.
"It is good that Lucas (Joao) is back again, he is more ready than last week. He's had around two and a half weeks of training. This is the life , if someone can't play someone will take his responsibility and we believe in all the players in the squad."
Hooper's fellow forward Steven Fletcher was also a concern having missed training at the early part of this week but he is now back, while Almen Abdi has been suffering from illness.
"Daniel Pudil is training OK, he still had limitations at the beginning of the week, he is getting better and better but he is back in training," added Carvalhal.
"Fletcher was out during the week but he is training again. Abdi was ill but we expect him training tomorrow and after that we will make decisions for the weekend."