Wolves’ hex over the Owls continued as the hosts ran out comfortable winners at Molineux.
A Bakary Sako penalty plus second half strikes from Benik Afobe and James Henry saw Wolves stroll to victory over Wednesday.
Wednesday were left to rue an agonising miss from Atdhe Nuhiu with the score at 1-0.
Nuhiu headed narrowly over on four minutes as the Owls started brightly against Wolves.
The big forward connected with regular supplier Jacques Maghoma but could not keep his header down.
Afobe fired wide for the hosts from a corner while Rajiv van La Parr’s low cross needed a strong hand from Keiren Westwood to prevent it from drifting into the net.
Tom Lees headed just over at the back post as he met Lewis McGugan’s well-placed free kick.
The came the opener. Claude Dielna conceded the penalty when he was harshly adjudged to have clipped Nouha Dicko who ran across him on his way into the box.
And Sako sent Westwood the wrong way from the spot to put the hosts in front after 18 minutes.
Kevin McDonald was in an excellent position to double the advantage but saw his strike kept out superbly by Westwood.
And Westwood was the hero again as he denied Dicko’s rasping drive at full stretch with the ball looking destined for the top corner.
Jack Price fired straight at Westwood as Wolves continued to threaten.
Wednesday had their best move of the match to that point when Chris Maguire sent over an excellent cross which Maghoma met and drew a fine save from Tomasz Kuszczak.
The Owls had started the half brightly with Maghoma firing narrowly wide after twisting and turning into the area.
And Nuhiu headed over the bar with a gilt-edged chance from a superb position.
Adding insult to injury, Wolves extended their lead soon after.
Former loanee Benik Afobe came back to haunt the Owls as he met Matt Doherty’s superb cross first time and volleyed in off the post.
Substitute James Henry curled in a beauty to put Wolves out of sight.
Henry was given the freedom of Molineux to cut in from the right and across the front of the box but produced a stunning finish into the top corner.
Wolves: Kuszczak; Doherty, Batth, Stearman (Ebanks-Landell 74), Golbourne; van La Parra (Henry 53), McDonald (Edwards 88), Price, Sako; Afobe, Dicko.
Subs: McCarey, Evans, Doyle, Hause
Owls: Westwood, Vermijl, Lees, Dielna, Helan, Maguire, McGugan, Hutchinson (Melo 77), Maghoma, Nuhiu, May (Lavery 64).
Subs: Kirkland, Buxton, Mattock, Lee, De Havilland
Ref: Simon Hooper