Sheffield United have been drawn away to fellow League One club Preston North End in the fourth round of the FA Cup.
United, who reached the semi-finals of the competition last season, drew 1-1 with Preston at Deepdale last August.
Either Everton or West Ham will face the winner of Doncaster Rovers and Bristol City away from home.
Chesterfield will head to Derby County should they see off Scunthorpe United tonight.
Cambridge United have been handed a dream home tie with 11-time winners Manchester United in the last 32.
The draw, which was held at Kingsmeadow, means the lowest-ranked side left in the competition will welcome Louis van Gaal’s Red Devils to Abbey Stadium on the weekend of January 24-25.
A total of 79 league places separate Richard Money’s League Two side with the third-placed Premier League outfit, but as has been seen on so many occasions before that does not always matter in the FA Cup.
Another draw that captures the imagination was Chelsea potentially being pitted against London rivals Millwall if the Lions come through their replay with Bradford City.
West Brom have also been given a tasty derby, with them making the short trip to St Andrews to take on Birmingham City.