Sheffield will hope to rediscover their home form when they take on another of the Division One play-off contenders with Carlton Town the visitors to the BT Local Business Stadium.
The visitors have become something of a bogey side for Club, going back to their days in the Northern Counties East League.
Club suffered a third home defeat on the trot when beaten 4-2 by Newcastle Town on Tuesday but Chris Dolby will be boosted by the return of Oliver Banks and James Gregory, though Steve Woolley is doubtful after picking up an injury that forced the wing-back off in the first half.
In the Premier Division, Stocksbridge Park Steels will look to bounce back from a disappointing 2-0 defeat at relegation rivals Whitby Town when they take on Northwich Victoria at Bracken Moor.
Steels are two points clear of the drop zone but know defeat against Northwich could see them tumble into the bottom four.
However, Gary Marrows side have every reason to feel confident they can bounce straight back after impressive wins against high-riding Matlock Town and North Ferriby United in the last two home outings.
Worksop Town take on runaway leaders FC Halifax Town at Cannon Park where boss Martin McIntosh is likely to hand a debut to winger Sam Duncum signed on a month’s loan from Blues Square North side Eastwood Town.
The Tigers have not been in action since the embarrassing 4-1 home defeat against struggling Ossett Town.
Frickley Athletic face a tough task as they bid to climb out of the bottom four with second-placed Colwyn Bay the visitors to Westfeld Lane.
Manager Peter Rinkcavage will be encouraged by his sides performance in the goalless draw against FC United of Manchester on Tuesday, a game the Blues should have won after squandering a second-half penalty.
Elsewhere, Matlock Town take on play-off rivals Kendal Town at Causeway Lane where they will look to put further daylight between the two teams.
The Gladiators go in the game third in the table, four places and four points ahead of the Cumbrians, who saw their play-off hopes take a knock with the 3-2 home defeat against Stocksbridge in the last outing.
Buxton travel to Burscough in search of three points that could see them climb back into a play-off place.