Sheffield Wednesday will travel to reigning Premier League champions Manchester City in the third round of the Capital One Cup.
The Owls, who have already knocked out Notts County and Burnley from the competition this season, will play the holders aiming to book a place in the last 16 next month.
Sheffield United, FA Cup semi-finalists last campaign, will fancy their chances of advancing after being handed an away tie at Leyton Orient, who triumphed at top flight club Aston Villa last night. The Blades reached the third round after defeating West Ham on penalties.
Doncaster Rovers face a trip to Championship strugglers Fulham.
The ties will take place during the week commencing Monday, September 22.