Hallam and Dinnington Town face crunch relegation showdowns, while at the other end of the table Parkgate take on leaders Farsley AFC at home.
Hallam face their biggest game of the season after their 4-2 home defeat against relegation rivals Liversedge on Tuesday, which saw the Blues slump to a 14th game without a win and swap places with the visitors at the foot of the table.
Kenny Geelan's weary troops take on another relegation candidate Hall Road Rangers at Sandygate in a must win game. Rangers are fifth from bottom, seven points better off than the Blues and with a game in hand. Hallam need to take all three points to drag the visitors back into the pack. Dinnington Town were beaten 3-1 by Tadcaster Albion this week, leaving Steve Toyne's side in trouble. They have the opportunity to repair some of the damage caused by a run of one win in the 18 league outings when they take on next to bottom Liversedge at Phoenix Park. Town are just a point clear of the drop zone and have played two more games than Liversedge, who will be in buoyant mood following the victory at Sandygate.
Parkgate's unbeaten 10 match league record will be put under scrutiny by leaders Farsley AFC as Doug Shelley's side bid to go top. Farsley, beaten 2-1 at Lincoln on Tuesday, are two points clear at the top having played three more games than the Steelmen who have not lost at home in the league since April.
Elsewhere, Armthorpe Welfare will look to continue their improvement at home to third-placed Bridling Town. De Bennett's side are up to 11th after winning three of the last four and the two sides are set to meet again in the reverse fixture next Tuesday.
In-form Maltby Main travel to seventh in the table Brighouse Town. The Miners have taken 21 points from the last 24 which has seen them rise to fifth in the table.
In Division One, Worsbrough Bridge Athletic entertain promotion hopefuls Pontefract Collieries. Bridge will aim to bounce back from their Wilkinson Sword Trophy 3-2 extra-time exit against Barton Town.
Rossington Main take on Eccleshill United boosted by a 6-1 Wilkinson Sword Trophy win over neighbours Brodsworth Welfare that ended the 11 match losing home streak. Askern Villa will hope to continue their promotion push at home against Bottesford Town after climbing to third following a 1-0 win at Hemsworth. Handsworth hope to put themselves back in promotion contention with a win at Leeds Carnegie. Russ Eagles's side are six points outside the top two but have two games in hand, while Brodsworth Welfare go to Hemsworth MW.
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