The wife of Sheffield Wednesday's fitness coach needs to raise £30,000 in six weeks to fund specialist cancer treatment she hopes will save her life.
Hayley Kalinins, aged 35, has raised over £134,000 in seven months to pay for treatment in Germany after British medics said there was nothing more they could do for her.
The mum-of-four, who is married to Owls fitness coach Andy Kalinins, is undergoing immunotherapy treatment, which is designed to boost the body's natural defences to fight cancer.
Hayley has secondary breast cancer, with tumours in her breast and lungs.
She said the treatment in Germany is working, claiming she has never felt as well since she was diagnosed five years ago.
But with all the money raised so far having been spent on her treatment, Hayley's husband Andy has issued an online appeal for help in raising more, with £30,000 needed over the next six weeks.
He said the couple have paid thousands themselves and have used up all their credit cards to fund the treatment.
He said: "The clinic is fantastic and a getting the most amazing results on a weekly basis and we believe they are going to give Hayley the results we all wish for.
"We are now facing a massive problem. The fund is completely empty.
"Hayley needs two more treatments before her next scan in six weeks. We really need everyone to get behind Hayley once again and pull together.
"We need a team of ongoing fundraisers. We need regular donors.
"We have put thousands in ourself and have nothing left on credit cards.
"Hayley has to continue on this treatment. We know it is working. The next year is crucial. We know remission is possible with their latest scientific advanced cancer therapies.
"Immunotherapy will not be available on the NHS for Hayley's type of secondary breast cancer for at least another five years. We have no time to wait.
"Hayley is the most amazing mother of our four children. They need her.
"If we can't raise the money. Hayley's treatment will stop. The cancer is aggressive and she won't survive. Please help."