Crookes, Crosspool and Ranmoor have been named as among some of the best places to live in Britain in a new survey.
The S10 postcode area - which also includes Broomhill, Fulwood and Redmires, is one of the top hotspots for young professionals buying homes across England and Wales, a report has found.
Didsbury in Manchester, Clifton in Bristol, central Cardiff, Jesmond in Newcastle and Reading were also among the most desirable places for professionals aged between 25 and 44 years old to buy a property, according to Lloyds Bank.
Lloyds' review looked at Land Registry house sales in the year to February 2016 and also used analysis of different sectors of the population by marketing consultancy CACI to make the findings.
Lloyds Bank mortgage director Mike Songer said: "Young professionals tend to have a professional or university qualification, are in well paid jobs and enjoy an urban lifestyle without the hustle and bustle of living in the city centre.
"Our research shows that aspiring young urbanites choose to settle in areas which give them the best of both worlds - attractive suburbs offering good amenities and quality of life, which are within easy reach of a larger city centre - and in many cases they are prepared to pay a premium to live there."
The research also found young professionals face paying a premium to live in their desired area - paying £88,000 more typically for a home in the postal district hotspots than a property in the wider town or city where they are located.
The survey said that the average house price in S10 is £239,625 while the average house price across Sheffield is £170,036 - meaning buyers pay a 41% premium to live in the area.