Sheffield businessmen will take aim at a charity clay pigeon shoot, and the money raised will transform thousands of people's lives.
The Mad4It charity shoot at Yeaveley Estate, Asbourne, is part of a campaign which strives to raise £250,000 for an innovative robotic assistant which will revolutionise brain surgery.
The ROSA Robot will also assist deep brain stimulation and the support treatment of epilepsy, Parkinson's and motor neurone disease.
Sheffield Hallam University will be the first in the country to get the robot.
The organiser of Thursday's shoot, Fiddler's Drive, Doncaster resident Tony Walton, said he hoped to contribute between £30,000 and £40,000 to Neurocare from the event.
The day will take on added poignancy as shooters remember a man who worked tirelessly to raise money for the charity.
Nick Wolstenholme died in 2015 after fighting a brain tumour.
Mr Wolstenholme, a Peak District businessman, started the annual shoot in 2002.
He raised thousands of pounds in the ensuing years.
"When he passed away, he left a hole in the fundraising," Mr Walton said.
"We took up the mantle.
"We all want to make some money for the charity."
Eleven teams of five shooters will take part.
Former England cricketer Geoff Miller will run an auction on the day.
A Ferrari race day for two, signed Manchester United polo shirt and pheasant shooting event will go to the highest bidders.
Four tickets to the England versus West Indies one-day cricket international at Trent Bridge are also up for grabs.
Neurocare says the robot is 'particularly successful' for surgical procedures in treating epilepsy.
The robot, according to the charity's website, is 52 per cent funded.