The M1 was shut in both directions yesterday when two lorries collided at Blackwell, near Tibshelf Services.
Emergency services were alerted to the smash on the southbound carriageway at 4.55am and an air ambulance was scrambled.
The collision involved one lorry running into the rear of the other.
One of the drivers sustained serious injuries and was receiving treatment at the Northern General Hospital yesterday.
Witnesses to the collision or anyone with information should call Derbyshire Police on 101.