Sheffield songstress Lucy Spraggan will be heading up the entertainment at this year’s Rotherham Hospice Midnight Memory Walk.
The event takes place on Friday, with about 700 people expected to take part.
It is the hospice’s biggest fundraiser of the year.
Lucy, from Stannington, who appeared on last year’s The X Factor, said: “We’ve all had a family member or a close friend affected by a terminal illness so it’s something we can all relate to.
“I’m looking forward to seeing people be a part of such a great cause. It should be a brilliant occasion.
“I wish everyone taking part the best of luck, and they should be very proud of themselves.”
She will be supported by other local acts, including Jessica Steele, from Sheffield, who appeared on BBC talent show The Voice.
She said: “I’m so excited to perform at this event, as it is absolutely fantastic what the hospice does for people.
“I really want to help raise as much money as possible.”
Also performing will be local band The Magnetics.
Members of Rotherham Teachers Student Academy will perform a sneak preview of hospice anthem I Smile, due to be released at the end of June.
On the stroke of midnight, Lucy will start the walkers off on a six or 10-mile walk around Rotherham.
Anne Giblin, hospice fundraiser, said: “The route is well lit and there will be plenty of friendly marshals around to cheer the walkers on.
“It is a wonderful night where people can remember and celebrate the life of a loved one.
“There is a real sense of fun, both before the walk sets off, and also out on the route. Many people make new friends on the night.
“We are thrilled with the number taking part.”