Some 67 people received life-changing new kidneys in Sheffield last year - using organs donated by 30 people who had died and a further 19 who are still living.
The figures have been released by NHS Blood and Transplant as part of their annual report into organ donation across the country.
In the city last year there were 17 patients whose families donated their kidneys following a brain death, up from 12 in the year March 2009 to March 2010.
There were also another 13 patients whose loved ones donated their kidneys following a circulatory death, an increase from six the year before.
From these 48 people underwent transplant procedures to receive a new kidney, often freeing them from life-restricting dialysis treatment.
A further 19 transplant operations took place using kidneys from living donors - although the figures reflected the national pattern and represented a dip from 23 the previous year.
Overall the number of people in Sheffield waiting on the active transplant list went down from 229 to 195.
The report reveals the numbers of organs donated by patients at hospitals across the region.
At Sheffield’s Northern General and Royal Hallamshire hospitals there were 17 donors last year, up from 11 the previous year - 12 of whom donated more than one organ, up from nine.
This equated to 32 kidneys, one heart, seven lungs, 13 livers and seven pancreas.
Andrew Davidson, Clinical Lead in Organ Donation at Sheffield Teaching Hospitals NHS Foundation Trust, said: “It is very encouraging to see more people signing up to the organ donation register.
“However, there are still thousands of patients waiting for a life saving transplant and many more organs are still needed.”
At Rotherham Hospital there was only one donor last year, down from two the year before. Two kidneys, a heart, two lungs and a liver were donated.
At Barnsley Hospital the number of donors doubled from two to four, but only two gave multiple donations. This resulted in eight kidneys, four lungs and two livers being donated.
At Doncaster Royal Infirmary the figures had gone up from no donors the year before, to five last year. Three donated multiple organs, resulting in 10 kidneys, one heart, three livers and one pancreas.
At Chesterfield Royal Infirmary the number of donors stayed the same at three, two of whom gave more than one organ. This resulted in six kidneys, three lungs and two livers offered for transplant.
Sally Johnson, director of organ donation and transplanation at NHS Blood and Transplant, urged people to register.
n Visit www.organdonation.nhs.uk or ring 0300 123 23 23 to sign up.