Experts shed fresh light on deadly disease

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New Sheffield University research could offer solutions into slowing down the progression of the deadly motor neurone disease.

Scientists conducted pioneering research assessing how the devastating and debilitating disease affects individual patients.

MND is an incurable disease destroying the body’s cells which control movement, causing progressive disability.

Present treatment options for those with MND only have a modest effect in improving the patient’s quality of life.

Professor Pamela Shaw and her research team worked with experts in Milan to investigate why the progression of MND following the onset of symptoms varies in speed, even in the presence of a known genetic cause of the condition. Two strains of the disease were monitored using genetically altered mice – one fast-acting, the other slow.

The researchers looked at the factors which might explain the differences observed in speed and severity in the progression of the disease.

They then sought to identify factors that control vulnerability or resistance to MND, in order to shed light on the elements important for the speed of motor neurone injury in human patients.