The former Sheffield City Airport runway is set to be dug up by the end of the year after the Government agreed a £1.8m loan.
The 50-acre site - officially called Sheffield Business Park Phase 2 - is set to get a new road and other infrastructure work aimed at making it ‘oven ready’ for companies to move on to and start building.
One of the first jobs, according to business park MD Graham Sadler, would be to take up all the Tarmac and level the site.
He added: “Once the ground is prepared we believe it will generate real interest, secure users and generate jobs, as happened at the Advanced Manufacturing Park.”
Contracts are currently being drawn up for one company to take a 10-acre portion, he added.
Earlier this year the Federation of Small Businesses mounted a campaign to reopen the airport, claiming to have the backing of a major investor.
Mr Sadler said he was contacted. But he has heard nothing since asking for details of how they intended to deliver the project.
Phase 2 is part of the Sheffield City Region Enterprise Zone which includes more than a dozen plots of land in Chesterfield, Rotherham and Barnsley. It offers companies fast-track planning and tax breaks.
The Government announced £100m to boost 18 Enterprise Zone sites across the country. A second piece of land in South Yorkshire - the Waverley site based around the Advanced Manufacturing Park near Catcliffe, Rotherham - will also receive infrastructure funds.