Faster trains between Sheffield and London launch in less than four weeks.
Operator East Midlands Trains is reducing the speediest journey time from two hours and seven minutes to two hours after a £70 million line improvement scheme.
Timetables for the new service are now available.
The faster service has been made possible by track improvements which mean trains can operate at 125mph on more stretches of the route.
The programme of changes completed by Network Rail over the last couple of years includes replacement of some level crossings with bridges, minor resignalling and work to realign parts of the track.
David Horne, East Midlands Trains’ managing director, said: “Along with our partners Network Rail, we’ve been working on a significant improvement scheme to deliver faster journey times from some of the key cities and towns on our network.
“Almost £70 million has been spent to enable our trains to run at speeds of up to 125mph on certain sections of our route, which will enable passengers in Sheffield to benefit from faster journeys to London.
“This is a hugely exciting scheme that will deliver benefits for the local economy and allow us to deliver a much improved service for our customers.”
Copies of the new timetable are now available online at eastmidlandstrains.co.uk and at East Midlands Trains’ stations.
In addition to the improved journey times, which launch from December 9, there will also be changes to many of the departure times and connection times.
Phil Verster, route managing director for Network Rail, said: “We are investing £70 million improving journey times on the Midland Main Line. This involves work on track and structures such as bridges and platforms to allow them to accommodate faster running.
“We are also removing a number of level crossings which helps increase line speed.
“The project will allow trains to run up to 125mph on sections of the route, bringing significant social and economic benefits to the East Midlands.”